If you’re intellectually honest, you have to admit that there’s not a ton of evidence one way or the other about the effects of transition on trans people. There has never been a randomized controlled trial of transition. Many studies use cisgender controls, which is sort of like studying the effect of chemotherapy by comparing chemotherapy patients to people whom have never had cancer. Few studies have any sort of long-term followup. The effects of taking hormones for forty, fifty, sixty years are basically unknown.
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